Hewlet McFarlane, Ph.D  Assistant Professor Samuel Mather Hall 411    (740) 427-5375  McFarlaneh@kenyon.edu

Ph.D.  Syracuse University     May, 1998

M.S.   Syracuse University     May, 1995 

B.S.    Syracuse University     May, 1991

   1998 
 
 

Professional History

8/92 - 7/97 Teaching Assistant (TA), Psychology Dept., Syracuse University.  Summers ‘94-'97 Instructor for “Foundation of Human Behavior,” Center for Academic Achievement, Syracuse University. 8/96 - 8/98 Graduate Student Representative of the Syracuse University Institutional Animal Care and Use Committee (IACUC).

 

Teaching Interests

The guiding principle in my teaching is the communication of the scientific method as a way of thinking, to the students. I try to emphasize that the scientific can method can be used in classes that are not traditionally considered “science classes” as well as in endeavors outside the classroom because of its relationship to critical thinking/logical analyses.

 

Research Interests

My current work relates to schizophrenia and depression.  In my laboratory, we examine the role that alterations in brain chemistry may play in the etiology of these disorders.  To accomplish this we study the role of the central serotonin (5-HT) system in the modulation of dopamine (DA) and Norepinephrine efflux in the medial prefrontal cortex of rats, using In Vivo Microdialysis.  In this method, drugs (e.g., antipsychotics) are infused directly into the brain of awake rats and the dialysate (fluid) collected is injected onto an HPLC.  This allows us to examine changes in brain chemistry in response to drug action on the brain.

 

Recent Publications (students shown in bold)

McFarlane, H.G., (1995). Psychoneuroimmunomodulation: Stress effects on, and classical conditioning of, the immune system. Bridges, Vol. 4 No. 1, 17-25.  Cornwell, C.A., Chang, J.W., Cole, B., Fukada, Y., Gianulli, T., Rathbone, E., McFarlane, H.G., and McGaugh, J.L. (1996). DSP-4 treatment influences olfactory preferences of developing rats.  Brain Research, Vol. 711, 26-33.  Mazei, M.S., Pluto, C.P., McFarlane, H.G., and Pehek, E.A. (1999).  Differential effects of dopamine uptake blockers in subregions of the rat medial prefrontal and anterior cingulate cortices.  Monitoring Molecules in Neuroscience, Proceedings from the 8th International Conference on In Vivo Methods, pp.69-70.  Pehek, E.A.,  McFarlane, H.G., Maguschak, K., Price, B., and Pluto, C.P (2001). M100, 907, a selective 5-HT2A antagonist, attenuates dopamine release in the rat medial prefrontal cortex (Brain Research, Vol. 888, Issue 1, pp.51-59).  Cornwell, C., Gavalchin, J., Dewey, T., McFarlane, H., Sarao, M.F.E.M., Coticchia, C., Gerlach, W., McLeod, H., and O’Leary, K. (1996). Differential housing has sexually dimorphic effects on odor preferences, immune cell phenotype, and weight loss in control and DSP-4 treated CD-1 Mice. Soc. Neurosci. Abstr. 22, 1127.  McFarlane, H.G., Henry, S., Dewey, T.H., and Cornwell, C.A. (1995). Odor preferences of control rats are altered by the number DSP-4 treated rats in the home cage. Soc. Neurosci. Abstr., 21, 1231.  Cornwell-Jones, C.A., McFarlane, H.G., and Fukada, Y., (1993). Altered responses to conspecific nest odors by DSP-4 treated rats and their control cagemates. Soc. Neurosci. Abstr., 19, 368.  McFarlane, H.G., Brown, P.  Adaniel, J.L, Diglio, D., Hamblin, N., Ballard, J., and Cornwell, C.A., (1998). DSP-4, a norepinephrine neurotoxin, impairs social habituation in male CD-1 mice. Soc. Neurosci. Abstr., 24, 1436.  McFarlane, H.G., and Pehek, E.A., (1999). The effects of the selective 5-HT2A antagonist MDL 100,907 on K+-stimulated DA release in the rat medial prefrontal cortex. Soc. Neurosci. Abstr., 25, 1214.

 

Committees, Organizations, and Groups

The Society for Neuroscience  The New York Academy of Sciences  8/98--present: Kenyon College Institutional Animal Care and Use Committee(IACUC)  8/99--present: Kenyon College Fellowships and Awards Committee  8/00--present: Kenyon College Academic Infractions Board

 

Current Projects

We are currently examining the role of the serotonin1A receptor on norepinephrine efflux in the prefrontal cortex.

 

The best thing about being at Kenyon is

 Too numerous to mention.
 
 

Hobbies and favorite things

 Playing my keyboard, watching movies (especially good science fiction), biking on the trail. 
 
 

One thing to do or accomplish in life

 Earn a pilot’s license
 

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